| dc.description.abstract | Six isolated compounds; Vismiaquinone A (CF1), γ-tocotrienol (CF2), δ-
tocotrienol (CF3), 7-geranyloxy-1,3-dihydroxyxanthone (CF4), Cochinchinone G (CF5),
Cochinchinone A (CF6) were isolated from ethylacetate extracts of Cratoxylum
cochinchinense. The isolation of hexanes extract of twigs of C. cochinchinense to
afforded six known compounds; Cochinchinone A (CT1), Dulcisxanthone F (CT2), ßmahostin
(CT3), 7-geranyl-1,3,7-trihydroxy-4-(3,3-dimethylallyl)-xanthone (CT4), 1,3,7-
trihydroxy-2,4-di-isopropylxanthone (CT5) และ Dulcisxanthone B (CT6). The structure
of isolated compounds were elucidated by basic NMR spectroscopy (1H, 13C, COSY,
HSQC, HMBC) and compared with previous literature reviews. All isolated compounds
were tested for in vitro cytotoxic activity against five human cancer cell lines. The
xanthone showed cytotoxicity more than other compounds and the polarity of
compounds played important role in cytotoxic activity. Furthermore, 1,3,7-trihydroxy-
2,4-di-isopropylxanthone (CT5) showed the most cytotoxic activity against five
human cancer cell lines; breast (BT474), lung (CHAGO), liver (Hep-G2), gastric (KATO-
3), and colon (SW-620) as 1.05, 0.46, 0.46, 0.63 and 3.11 μg/mL, respectively. | en_US |
